Immunopathogenesis versus Protection in Dengue Virus Infections
نویسندگان
چکیده
منابع مشابه
Immunopathogenesis Versus Protection in Dengue Virus Infections.
Dengue viruses (DENV) are mosquito-borne viruses that cause significant morbidity. The existence of four serotypes of DENV with partial immunologic cross-reactivity creates the opportunity for individuals to experience multiple acute DENV infections over the course of their lifetimes. Research over the past several years has revealed complex interactions between DENV and the human innate and ad...
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Dengue virus infections cause significant morbidity and mortality worldwide. Although initially believed to be an infection afflicting mainly the paediatric age group, this infection has been rapidly spreading across all age groups, with the first reports of the pandemic from South-East Asia dating back to the 1950s. Dengue virus belongs to the genus Flavivirus and has four serotypes, each of w...
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Dengue diagnosis was one of the topics discussed at "the adult dengue" presentations. In this paper, a review is presented focusing on the main challenges of dengue laboratory diagnosis. Accurate and efficient diagnosis of dengue is important for clinical care, surveillance support, pathogenesis studies, and vaccine research. Laboratory diagnosis is also important for case confirmation. Laborat...
متن کاملEarly T-cell responses to dengue virus epitopes in Vietnamese adults with secondary dengue virus infections.
T-cell responses to dengue viruses may be important in both protective immunity and pathogenesis. This study of 48 Vietnamese adults with secondary dengue virus infections defined the breadth and magnitude of peripheral T-cell responses to 260 overlapping peptide antigens derived from a dengue virus serotype 2 (DV2) isolate. Forty-seven different peptides evoked significant gamma interferon enz...
متن کاملSymptomatic Versus Inapparent Outcome in Repeat Dengue Virus Infections Is Influenced by the Time Interval between Infections and Study Year
Four dengue virus serotypes (DENV1-4) circulate globally, causing more human illness than any other arthropod-borne virus. Dengue can present as a range of clinical manifestations from undifferentiated fever to Dengue Fever to severe, life-threatening syndromes. However, most DENV infections are inapparent. Yet, little is known about determinants of inapparent versus symptomatic DENV infection ...
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ژورنال
عنوان ژورنال: Current Tropical Medicine Reports
سال: 2013
ISSN: 2196-3045
DOI: 10.1007/s40475-013-0009-0